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Drugs with a possible risk for QT prolongation that should be used cautiously with cyclobenzaprine include the beta-agonists. This risk is generally higher at elevated drugs concentrations. Ventolin spacer buy HFA or placebo HFA was delivered with either an AeroChamber Plus Valved Holding Chamber or an Optichamber Valved Holding Chamber with mask 3 times daily. Peak effect was defined as the maximum increase above baseline (expressed as a percentage) achieved at any time during the 6-hour serial day.